Immunization with Rabies Inactivitied Vaccine, PV2061 Strain elicits potent immune responses and protects dogs against lethal challenge

Abstract

Despite the availability of efficacious vaccines for animals and humans, rabies is still a major zoonosis. Prevention of rabies in dogs is key for reducing the risk of transmission of this deadly disease to humans. The protection of immunized animals was largely dependent on the induced humoral immune response. The objective of this study was to validate the Rabies Inactivitied Vaccine, PV2061Strain on one vaccination. 14000 dogs of different ages were involved in this research. The result showed that the vaccinated dogs were induced a strong and sustained antibody response and almost had no clinical manifestations. What is more, all vaccinated animals (30 dogs selected randomly from vaccinated dogs) were protected against virulent rabies challenge carried out 1 year after vaccination. These results validated 1 year duration of immunity after a vaccination with PV2061.